<?xml version="1.0" encoding="us-ascii"?>
<!-- Created by Toppan Merrill -->
<!--XBRL document created with Toppan Merrill Bridge  9.4.0.81 -->
<!--Based on XBRL 2.1-->
<!--Created on: 11/12/2019 2:10:34 PM-->
<!--Modified on: 11/12/2019 2:10:34 PM-->
<xsd:schema targetNamespace="http://www.deitaxonomy.com/20190930" attributeFormDefault="unqualified" elementFormDefault="qualified" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:invest="http://xbrl.sec.gov/invest/2013-01-31" xmlns:dei="http://xbrl.sec.gov/dei/2019-01-31" xmlns:us-gaap="http://fasb.org/us-gaap/2019-01-31" xmlns:srt-types="http://fasb.org/srt-types/2019-01-31" xmlns:us-roles="http://fasb.org/us-roles/2019-01-31" xmlns:ref="http://www.xbrl.org/2006/ref" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:nonnum="http://www.xbrl.org/dtr/type/non-numeric" xmlns:currency="http://xbrl.sec.gov/currency/2017-01-31" xmlns:xl="http://www.xbrl.org/2003/XLink" xmlns:naics="http://xbrl.sec.gov/naics/2017-01-31" xmlns:srt-roles="http://fasb.org/srt-roles/2019-01-31" xmlns:country="http://xbrl.sec.gov/country/2017-01-31" xmlns:utr="http://www.xbrl.org/2009/utr" xmlns:srt="http://fasb.org/srt/2019-01-31" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:exch="http://xbrl.sec.gov/exch/2019-01-31" xmlns:num="http://www.xbrl.org/dtr/type/numeric" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:sic="http://xbrl.sec.gov/sic/2011-01-31" xmlns:us-types="http://fasb.org/us-types/2019-01-31" xmlns:negated="http://www.xbrl.org/2009/role/negated" xmlns:stpr="http://xbrl.sec.gov/stpr/2018-01-31" xmlns:attributeFormDefault="unqualified" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:ocgn="http://www.deitaxonomy.com/20190930">
  <xsd:annotation>
    <xsd:appinfo>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/StatementCondensedConsolidatedBalanceSheets" id="StatementCondensedConsolidatedBalanceSheets">
        <link:definition>00100 - Statement - CONDENSED CONSOLIDATED BALANCE SHEETS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/StatementCondensedConsolidatedStatementsOfOperationsAndComprehensiveLoss" id="StatementCondensedConsolidatedStatementsOfOperationsAndComprehensiveLoss">
        <link:definition>00200 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/StatementCondensedConsolidatedStatementsOfCashFlows" id="StatementCondensedConsolidatedStatementsOfCashFlows">
        <link:definition>00400 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureSummaryOfSignificantAccountingPoliciesDetails" id="DisclosureSummaryOfSignificantAccountingPoliciesDetails">
        <link:definition>40201 - Disclosure - Summary of Significant Accounting Policies (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureMergerAndFinancingMergerWithHistogenicsDetails" id="DisclosureMergerAndFinancingMergerWithHistogenicsDetails">
        <link:definition>40403 - Disclosure - Merger and Financing - Merger with Histogenics (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureBalanceSheetDetailDetails" id="DisclosureBalanceSheetDetailDetails">
        <link:definition>40701 - Disclosure - Balance Sheet Detail (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureCommitmentsOperatingLeasesComponentsOfLeaseExpenseDetails" id="DisclosureCommitmentsOperatingLeasesComponentsOfLeaseExpenseDetails">
        <link:definition>41002 - Disclosure - Commitments - Operating leases, components of lease expense (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureCommitmentsOperatingLeasesSupplementalBalanceSheetInformationDetails" id="DisclosureCommitmentsOperatingLeasesSupplementalBalanceSheetInformationDetails">
        <link:definition>41003 - Disclosure - Commitments - Operating leases, supplemental balance sheet information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureCommitmentsOperatingLeasesFutureMinimumLeasePaymentsDetails" id="DisclosureCommitmentsOperatingLeasesFutureMinimumLeasePaymentsDetails">
        <link:definition>41005 - Disclosure - Commitments - Operating leases, future minimum lease payments (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureCommitmentsOperatingLeasesFutureMinimumLeasePaymentsDetailsCalc2" id="DisclosureCommitmentsOperatingLeasesFutureMinimumLeasePaymentsDetailsCalc2">
        <link:definition>41005 - Disclosure - Commitments - Operating leases, future minimum lease payments (Details) - Calc-2</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureCommitmentsFinanceLeasesFutureMinimumLeasePaymentsDetails" id="DisclosureCommitmentsFinanceLeasesFutureMinimumLeasePaymentsDetails">
        <link:definition>41007 - Disclosure - Commitments - Finance leases, future minimum lease payments (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureCommitmentsFinanceLeasesFutureMinimumLeasePaymentsDetailsCalc2" id="DisclosureCommitmentsFinanceLeasesFutureMinimumLeasePaymentsDetailsCalc2">
        <link:definition>41007 - Disclosure - Commitments - Finance leases, future minimum lease payments (Details) - Calc-2</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/StatementCondensedConsolidatedStatementsOfStockholdersEquityDeficit" id="StatementCondensedConsolidatedStatementsOfStockholdersEquityDeficit">
        <link:definition>00300 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (DEFICIT)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureDebtTables" id="DisclosureDebtTables">
        <link:definition>30903 - Disclosure - Debt (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureNatureOfBusinessReverseStockSplitDetails" id="DisclosureNatureOfBusinessReverseStockSplitDetails">
        <link:definition>40101 - Disclosure - Nature of Business - Reverse Stock Split (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureNatureOfBusinessGoingConcernDetails" id="DisclosureNatureOfBusinessGoingConcernDetails">
        <link:definition>40102 - Disclosure - Nature of Business - Going Concern (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureRecentAccountingPronouncementsDetails" id="DisclosureRecentAccountingPronouncementsDetails">
        <link:definition>40301 - Disclosure - Recent Accounting Pronouncements (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureMergerAndFinancingPreMergerFinancingDetails" id="DisclosureMergerAndFinancingPreMergerFinancingDetails">
        <link:definition>40401 - Disclosure - Merger and Financing - Pre-Merger Financing (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureMergerAndFinancingEquityOwnershipHeldDetails" id="DisclosureMergerAndFinancingEquityOwnershipHeldDetails">
        <link:definition>40402 - Disclosure - Merger and Financing - Equity Ownership Held (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureNetLossPerShareOfCommonStockDetails" id="DisclosureNetLossPerShareOfCommonStockDetails">
        <link:definition>40501 - Disclosure - Net Loss Per Share of Common Stock (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureLicenseAndCollaborationAgreementsDetails" id="DisclosureLicenseAndCollaborationAgreementsDetails">
        <link:definition>40601 - Disclosure - License and Collaboration Agreements (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureEquityTransactionsDetails" id="DisclosureEquityTransactionsDetails">
        <link:definition>40801 - Disclosure - Equity Transactions (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureDebtEb5LoanDetails" id="DisclosureDebtEb5LoanDetails">
        <link:definition>40901 - Disclosure - Debt - EB 5 LOAN (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureDebtConvertibleNotesDetails" id="DisclosureDebtConvertibleNotesDetails">
        <link:definition>40902 - Disclosure - Debt - Convertible Notes (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureDebtConvertibleNotesDerivativeLiabilityActivityDetails" id="DisclosureDebtConvertibleNotesDerivativeLiabilityActivityDetails">
        <link:definition>40903 - Disclosure - Debt - Convertible Notes Derivative Liability Activity (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureDebtConvertibleNotesOtherInformationDetails" id="DisclosureDebtConvertibleNotesOtherInformationDetails">
        <link:definition>40904 - Disclosure - Debt - Convertible Notes Other Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureDebtConvertiblePromissoryNotesDetails" id="DisclosureDebtConvertiblePromissoryNotesDetails">
        <link:definition>40905 - Disclosure - Debt - Convertible Promissory Notes (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureDebtConvertiblePromissoryNotesTableDetails" id="DisclosureDebtConvertiblePromissoryNotesTableDetails">
        <link:definition>40906 - Disclosure - Debt - Convertible Promissory Notes - Table (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureDebtSeniorSecuredConvertibleNotesDetails" id="DisclosureDebtSeniorSecuredConvertibleNotesDetails">
        <link:definition>40907 - Disclosure - Debt - Senior Secured Convertible Notes (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureDebtSeniorSecuredConvertibleNotesTableDetails" id="DisclosureDebtSeniorSecuredConvertibleNotesTableDetails">
        <link:definition>40908 - Disclosure - Debt - Senior Secured Convertible Notes - Table (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureCommitmentsDetails" id="DisclosureCommitmentsDetails">
        <link:definition>41001 - Disclosure - Commitments (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureCommitmentsFinanceLeasesDetails" id="DisclosureCommitmentsFinanceLeasesDetails">
        <link:definition>41006 - Disclosure - Commitments - Finance leases (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosurePreMergerFinancingWarrantsDetails" id="DisclosurePreMergerFinancingWarrantsDetails">
        <link:definition>41101 - Disclosure - Pre-Merger Financing Warrants (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureSubsequentIssuanceOfWarrantsDetails" id="DisclosureSubsequentIssuanceOfWarrantsDetails">
        <link:definition>41201 - Disclosure - Subsequent - Issuance Of Warrants (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureSubsequentEventsNeocartIntangibleAssetHeldForSaleDetails" id="DisclosureSubsequentEventsNeocartIntangibleAssetHeldForSaleDetails">
        <link:definition>41202 - Disclosure - Subsequent Events - NeoCart Intangible Asset Held for Sale (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureSubsequentEventsFormS3RegistrationStatementAndShareRepurchaseDetails" id="DisclosureSubsequentEventsFormS3RegistrationStatementAndShareRepurchaseDetails">
        <link:definition>41203 - Disclosure - Subsequent Events - Form S-3 Registration Statement and Share Repurchase (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DocumentDocumentAndEntityInformation" id="DocumentDocumentAndEntityInformation">
        <link:definition>00090 - Document - Document and Entity Information</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/StatementCondensedConsolidatedBalanceSheetsParenthetical" id="StatementCondensedConsolidatedBalanceSheetsParenthetical">
        <link:definition>00105 - Statement - CONDENSED CONSOLIDATED BALANCE SHEETS (Parenthetical)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/StatementCondensedConsolidatedStatementsOfStockholdersEquityDeficitParenthetical" id="StatementCondensedConsolidatedStatementsOfStockholdersEquityDeficitParenthetical">
        <link:definition>00305 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (DEFICIT) (Parenthetical)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureNatureOfBusiness" id="DisclosureNatureOfBusiness">
        <link:definition>10101 - Disclosure - Nature of Business</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureSummaryOfSignificantAccountingPolicies" id="DisclosureSummaryOfSignificantAccountingPolicies">
        <link:definition>10201 - Disclosure - Summary of Significant Accounting Policies</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureRecentAccountingPronouncements" id="DisclosureRecentAccountingPronouncements">
        <link:definition>10301 - Disclosure - Recent Accounting Pronouncements</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureMergeAndFinancing" id="DisclosureMergeAndFinancing">
        <link:definition>10401 - Disclosure - Merge and Financing</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureNetLossPerShareOfCommonStock" id="DisclosureNetLossPerShareOfCommonStock">
        <link:definition>10501 - Disclosure - Net Loss Per Share of Common Stock</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureLicenseAndCollaborationAgreements" id="DisclosureLicenseAndCollaborationAgreements">
        <link:definition>10601 - Disclosure - License and Collaboration Agreements</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureBalanceSheetDetail" id="DisclosureBalanceSheetDetail">
        <link:definition>10701 - Disclosure - Balance Sheet Detail</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureEquityTransactions" id="DisclosureEquityTransactions">
        <link:definition>10801 - Disclosure - Equity Transactions</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureDebt" id="DisclosureDebt">
        <link:definition>10901 - Disclosure - Debt</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureCommitments" id="DisclosureCommitments">
        <link:definition>11001 - Disclosure - Commitments</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosurePreMergerFinancingWarrants" id="DisclosurePreMergerFinancingWarrants">
        <link:definition>11101 - Disclosure - Pre-Merger Financing Warrants</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureSubsequentEvents" id="DisclosureSubsequentEvents">
        <link:definition>11201 - Disclosure - Subsequent Events</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureSummaryOfSignificantAccountingPoliciesPolicies" id="DisclosureSummaryOfSignificantAccountingPoliciesPolicies">
        <link:definition>20202 - Disclosure - Summary of Significant Accounting Policies (Policies)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureSummaryOfSignificantAccountingPoliciesTables" id="DisclosureSummaryOfSignificantAccountingPoliciesTables">
        <link:definition>30203 - Disclosure - Summary of Significant Accounting Policies (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureMergerAndFinancingTables" id="DisclosureMergerAndFinancingTables">
        <link:definition>30403 - Disclosure - Merger and Financing (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureNetLossPerShareOfCommonStockTables" id="DisclosureNetLossPerShareOfCommonStockTables">
        <link:definition>30503 - Disclosure - Net Loss Per Share of Common Stock (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureBalanceSheetDetailTables" id="DisclosureBalanceSheetDetailTables">
        <link:definition>30701 - Disclosure - Balance Sheet Detail (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureCommitmentsTables" id="DisclosureCommitmentsTables">
        <link:definition>31003 - Disclosure - Commitments (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosurePreMergerFinancingWarrantsTables" id="DisclosurePreMergerFinancingWarrantsTables">
        <link:definition>31103 - Disclosure - Pre-Merger Financing Warrants (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.deitaxonomy.com/role/DisclosureCommitmentsOperatingLeasesSupplementalCashFlowInformationDetails" id="DisclosureCommitmentsOperatingLeasesSupplementalCashFlowInformationDetails">
        <link:definition>41004 - Disclosure - Commitments - Operating leases, supplemental cash flow information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:linkbaseRef xlink:type="simple" xlink:href="ocgn-20190930_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" />
      <link:linkbaseRef xlink:type="simple" xlink:href="ocgn-20190930_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" />
      <link:linkbaseRef xlink:type="simple" xlink:href="ocgn-20190930_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" />
      <link:linkbaseRef xlink:type="simple" xlink:href="ocgn-20190930_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:title="Calculation Links, all" />
    </xsd:appinfo>
  </xsd:annotation>
  <xsd:import namespace="http://www.xbrl.org/dtr/type/numeric" schemaLocation="http://www.xbrl.org/dtr/type/numeric-2009-12-16.xsd" />
  <xsd:import namespace="http://www.xbrl.org/dtr/type/non-numeric" schemaLocation="http://www.xbrl.org/dtr/type/nonNumeric-2009-12-16.xsd" />
  <xsd:import namespace="http://www.xbrl.org/2009/role/negated" schemaLocation="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd" />
  <xsd:import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd" />
  <xsd:import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd" />
  <xsd:import namespace="http://xbrl.sec.gov/dei/2019-01-31" schemaLocation="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd" />
  <import namespace="http://fasb.org/us-roles/2019-01-31" schemaLocation="http://xbrl.fasb.org/us-gaap/2019/elts/us-roles-2019-01-31.xsd" xmlns="http://www.w3.org/2001/XMLSchema" />
  <import namespace="http://fasb.org/us-gaap/2019-01-31" schemaLocation="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd" xmlns="http://www.w3.org/2001/XMLSchema" />
  <import namespace="http://fasb.org/srt/2019-01-31" schemaLocation="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd" xmlns="http://www.w3.org/2001/XMLSchema" />
  <xsd:element name="DocumentAndEntityInformationAbstract" id="ocgn_DocumentAndEntityInformationAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element id="ocgn_SeniorSecuredConvertibleNotesMember" name="SeniorSecuredConvertibleNotesMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_ConvertiblePromissoryNotesMember" name="ConvertiblePromissoryNotesMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_ChangesInFairValueOfEmbeddedDerivativeTableTextBlock" name="ChangesInFairValueOfEmbeddedDerivativeTableTextBlock" nillable="true" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_EB5ProgramBorrowingsMember" name="EB5ProgramBorrowingsMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_LineOfCreditBorrowingEachDraw" name="LineOfCreditBorrowingEachDraw" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_ConvertibleDebtJanuary2018Member" name="ConvertibleDebtJanuary2018Member" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_ConvertibleDebtJune2018Member" name="ConvertibleDebtJune2018Member" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_ConvertibleDebtNovember2018Member" name="ConvertibleDebtNovember2018Member" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_ConvertibleDebtDecember2018Member" name="ConvertibleDebtDecember2018Member" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_ConvertibleDebtJanuary2019Member" name="ConvertibleDebtJanuary2019Member" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_ConvertibleDebtFebruary2019Member" name="ConvertibleDebtFebruary2019Member" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_ConvertibleDebtConversionFeatureMember" name="ConvertibleDebtConversionFeatureMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_ConvertibleDebtChangeControlFeatureMember" name="ConvertibleDebtChangeControlFeatureMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_ConvertibleDebtEquityFinancingTrigger" name="ConvertibleDebtEquityFinancingTrigger" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_ConvertibleDebtEquityFinancingTriggeredDiscount" name="ConvertibleDebtEquityFinancingTriggeredDiscount" nillable="true" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_DebtRedemptionFeatureMember" name="DebtRedemptionFeatureMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_DebtOffsetAgainstInvestorsPriorToMerger" name="DebtOffsetAgainstInvestorsPriorToMerger" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_DebtRedemptionMultipleUponDefault" name="DebtRedemptionMultipleUponDefault" nillable="true" type="xbrli:pureItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_CollaborationAgreementTerm" name="CollaborationAgreementTerm" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_ScheduleOfCashAndCashEquivalentsRestrictedCashTableTextBlock" name="ScheduleOfCashAndCashEquivalentsRestrictedCashTableTextBlock" nillable="true" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_SupplementalBalanceSheetInformationLeasesTableTextBlock" name="SupplementalBalanceSheetInformationLeasesTableTextBlock" nillable="true" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_ResearchAndDevelopmentExpensesCurrent" name="ResearchAndDevelopmentExpensesCurrent" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_AccountsPayableClinical" name="AccountsPayableClinical" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_AccountsPayableConsulting" name="AccountsPayableConsulting" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_SecuritiesPurchaseAgreementMember" name="SecuritiesPurchaseAgreementMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_NumberOfSharesAgreedToIssuePriorToMergerToInvestors" name="NumberOfSharesAgreedToIssuePriorToMergerToInvestors" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_NumberOfAdditionalSharesAgreedToIssuePriorToMergerToInvestors" name="NumberOfAdditionalSharesAgreedToIssuePriorToMergerToInvestors" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_GainsLossesOnConversionOfDebt" name="GainsLossesOnConversionOfDebt" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_NonCashInterestExpense" name="NonCashInterestExpense" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_NoncashOrPartNoncashOperatingLeaseRightOfUseAsset" name="NoncashOrPartNoncashOperatingLeaseRightOfUseAsset" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiabilityActivity" name="EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiabilityActivity" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_DeferredGrantProceedsCurrent" name="DeferredGrantProceedsCurrent" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_HistogenicsCorporationMember" name="HistogenicsCorporationMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_EquityHoldersOfOcugenIncPerMergerMember" name="EquityHoldersOfOcugenIncPerMergerMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_EquityHoldersOfHistogenicsCorporationMember" name="EquityHoldersOfHistogenicsCorporationMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_FinanceLeasedEquipmentMember" name="FinanceLeasedEquipmentMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_IncreaseDecreaseInDeferredRent" name="IncreaseDecreaseInDeferredRent" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_ConvertibleDebtEquityFinancingTriggeredRevisedAgreementActualDiscount" name="ConvertibleDebtEquityFinancingTriggeredRevisedAgreementActualDiscount" nillable="true" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_NoncashOrPartNoncashAmountOfDeferredTransactionCost" name="NoncashOrPartNoncashAmountOfDeferredTransactionCost" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_DeferredEquityIssuanceCostIncurredDuringNoncashOrPartialNoncashTransaction" name="DeferredEquityIssuanceCostIncurredDuringNoncashOrPartialNoncashTransaction" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_AssetHeldForSalePolicyTextBlock" name="AssetHeldForSalePolicyTextBlock" nillable="true" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_SeriesWarrantsMember" name="SeriesWarrantsMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_SeriesBWarrantsMember" name="SeriesBWarrantsMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_ClassOfWarrantOrRightTermOfWarrantsOrRights" name="ClassOfWarrantOrRightTermOfWarrantsOrRights" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_ClassOfWarrantOrRightConditionForExpirationTradingDay" name="ClassOfWarrantOrRightConditionForExpirationTradingDay" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_ClassOfWarrantOrRightExercisePriceDeterminationNumberOfTradingDaysConsidered" name="ClassOfWarrantOrRightExercisePriceDeterminationNumberOfTradingDaysConsidered" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_ClassOfWarrantOrRightExercisePriceDeterminationDividingFactor" name="ClassOfWarrantOrRightExercisePriceDeterminationDividingFactor" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_AssetPurchaseAgreementCashConsideration" name="AssetPurchaseAgreementCashConsideration" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_CommonStockSharesToBeSoldBySellingShareholders" name="CommonStockSharesToBeSoldBySellingShareholders" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_ReverseMergerAndFinancingDisclosureTable" name="ReverseMergerAndFinancingDisclosureTable" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_ReverseMergerAndFinancingDisclosureLineItems" name="ReverseMergerAndFinancingDisclosureLineItems" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_NumberOfConvertedInitialSharesAgreedToIssuePriorToMergerToInvestors" name="NumberOfConvertedInitialSharesAgreedToIssuePriorToMergerToInvestors" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_NumberOfConvertedAdditionalSharesAgreedToIssuePriorToMergerToInvestors" name="NumberOfConvertedAdditionalSharesAgreedToIssuePriorToMergerToInvestors" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_StockIssuanceCostsRecognized" name="StockIssuanceCostsRecognized" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_AssetsHeldForSale" name="AssetsHeldForSale" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_SeriesCWarrantsMember" name="SeriesCWarrantsMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_ClassOfWarrantOrRightsIssuanceNumberOfTradingDaysAfterConsummationOfMerger" name="ClassOfWarrantOrRightsIssuanceNumberOfTradingDaysAfterConsummationOfMerger" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_ReverseStockSplitExchangeRatePerShare" name="ReverseStockSplitExchangeRatePerShare" nillable="true" type="num:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_SeniorSecuredConvertibleNotesMay2019Member" name="SeniorSecuredConvertibleNotesMay2019Member" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_SeniorSecuredConvertibleNotesJune2019Member" name="SeniorSecuredConvertibleNotesJune2019Member" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiabilityWarrants" name="EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiabilityWarrants" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_BusinessCombinationIssuedSharesExchangeRate" name="BusinessCombinationIssuedSharesExchangeRate" nillable="true" type="num:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_CollaborationAgreementWithCansinoBiologicsMember" name="CollaborationAgreementWithCansinoBiologicsMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_CollaborationAgreementTerminationDevelopmentCostStatement" name="CollaborationAgreementTerminationDevelopmentCostStatement" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_CollaborationAgreementTerminationDevelopmentCostPayment" name="CollaborationAgreementTerminationDevelopmentCostPayment" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_ConvertedAdditionalSharesThresholdReleaseTrigger" name="ConvertedAdditionalSharesThresholdReleaseTrigger" nillable="true" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_ConvertedAdditionalSharesThresholdReleaseTriggerPeriod" name="ConvertedAdditionalSharesThresholdReleaseTriggerPeriod" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_StockIssuedDuringPeriodPreMergerValue" name="StockIssuedDuringPeriodPreMergerValue" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_StockIssuedDuringPeriodPreMergerShares" name="StockIssuedDuringPeriodPreMergerShares" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_CostsRelatedToIssuanceOfStockUnderPreMerger" name="CostsRelatedToIssuanceOfStockUnderPreMerger" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_SeriesWarrantsAndSeriesCWarrantsMember" name="SeriesWarrantsAndSeriesCWarrantsMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_PreMergerFinancingWarrantsAbstract" name="PreMergerFinancingWarrantsAbstract" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_PercentageOfExcessCommonStockOnPreMergerFinancingWarrantsOne" name="PercentageOfExcessCommonStockOnPreMergerFinancingWarrantsOne" nillable="true" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_PercentageOfExcessCommonStockOnPreMergerFinancingWarrantsTwo" name="PercentageOfExcessCommonStockOnPreMergerFinancingWarrantsTwo" nillable="true" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_PercentageOfAmountOnMarketValueForFailureToIssueCommonStockOnPreMergerFinancingWarrants" name="PercentageOfAmountOnMarketValueForFailureToIssueCommonStockOnPreMergerFinancingWarrants" nillable="true" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_ProceedsFromPreMergerFinancingFinancingActivities" name="ProceedsFromPreMergerFinancingFinancingActivities" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_ConvertedAdditionalSharesThresholdReleaseTriggerPrice" name="ConvertedAdditionalSharesThresholdReleaseTriggerPrice" nillable="true" type="num:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_PreMergerFinancingWarrantsTextBlock" name="PreMergerFinancingWarrantsTextBlock" nillable="true" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_PercentageOfIncreaseInPurchasePriceOfAssetPerMonth" name="PercentageOfIncreaseInPurchasePriceOfAssetPerMonth" nillable="true" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_NetProceedsFromReverseMerger" name="NetProceedsFromReverseMerger" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_DerivativeInstrumentsAndHedgingActivitiesDisclosurePolicyTextBlock" name="DerivativeInstrumentsAndHedgingActivitiesDisclosurePolicyTextBlock" nillable="true" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_MaximumClassOfWarrantsOrRightsIssuable" name="MaximumClassOfWarrantsOrRightsIssuable" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_ClassOfWarrantOrRightNumberExercised" name="ClassOfWarrantOrRightNumberExercised" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_StockIssuedDuringPeriodValueReverseAssetAcquisition" name="StockIssuedDuringPeriodValueReverseAssetAcquisition" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_StockIssuedDuringPeriodSharesReverseAssetAcquisition" name="StockIssuedDuringPeriodSharesReverseAssetAcquisition" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_CostsRelatedToIssuanceOfStockUnderReverseAssetAcquisition" name="CostsRelatedToIssuanceOfStockUnderReverseAssetAcquisition" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_MergerAcquisitionCostsIncurred" name="MergerAcquisitionCostsIncurred" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ocgn_AdjustmentsToAdditionalPaidInCapitalMergerRelatedCosts" name="AdjustmentsToAdditionalPaidInCapitalMergerRelatedCosts" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
</xsd:schema>
